FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Kreis Leslie W.
  2. Issuer Name and Ticker or Trading Symbol
Lantern Pharma Inc. [LTRN]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O LANTERN PHARMA INC., 1920 MCKINNEY AVENUE, 7TH FLOOR
3. Date of Earliest Transaction (Month/Day/Year)
11/04/2021
(Street)

DALLAS, TX 75201
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock               503,606 I By Bios Fund I, LP (1) (2) (4)
Common Stock               294,557 I By Bios Fund I QP, LP (1) (2) (4)
Common Stock               204,723 I By Bios Fund II, LP (1) (2) (4)
Common Stock               668,738 I By Bios Fund II QP, LP (1) (2) (4)
Common Stock               89,522 I By Bios Fund II NT, LP (1) (2) (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option $ 10.32 11/04/2021   A   3,200     (3) 11/04/2031 Common Stock 3,200 $ 0 3,200 I (3) (4) By BP Directors, LP (1) (2) (4)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Kreis Leslie W.
C/O LANTERN PHARMA INC.
1920 MCKINNEY AVENUE, 7TH FLOOR
DALLAS, TX 75201
  X   X    
BP Directors, LP
1751 RIVER RUN, SUITE 400
FORT WORTH, TX 76107
    X    
Bios Equity Partners, LP
1751 RIVER RUN, SUITE 400
FORT WORTH, TX 76107
    X    
Cavu Management, LP
1751 RIVER RUN, SUITE 400
FORT WORTH, TX 76107
    X    
BIOS Capital Management, LP
1751 RIVER RUN
SUITE 400
FORT WORTH, TX 76107
    X    
Cavu Advisors, LLC
1751 RIVER RUN, SUITE 400
FORT WORTH, TX 76107
    X    
BIOS Advisors GP, LLC
1751 RIVER RUN
SUITE 400
FORT WORTH, TX 76107
    X    
Fletcher Aaron G.L.
1751 RIVER RUN
SUITE 400
FT WORTH, TX 76107
    X    

Signatures

 /s/ Leslie W. Kreis, Jr.   11/08/2021
**Signature of Reporting Person Date

 BP Directors, LP, By: Bios Equity Partners, LP, its general partner, By: Cavu Management, LP, its general partner, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager   11/08/2021
**Signature of Reporting Person Date

 Bios Equity Partners, LP, By: Cavu Management, LP, its general partner, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager   11/08/2021
**Signature of Reporting Person Date

 Cavu Management, LP, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager   11/08/2021
**Signature of Reporting Person Date

 Bios Capital Management, LP, By: Bios Advisors GP, LLC, its general partner, By /s/ Aaron Glenn Louis Fletcher, Manager   11/08/2021
**Signature of Reporting Person Date

 Cavu Advisors, LLC, By: /s/ Leslie W. Kreis, Jr, Manager   11/08/2021
**Signature of Reporting Person Date

 Bios Advisors GP, LLC, By: /s/ Aaron Glenn Louis Fletcher, Manager   11/08/2021
**Signature of Reporting Person Date

 /s/ Aaron Glenn Louis Fletcher   11/08/2021
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Bios Equity Partners, LP ("Bios Equity I") is the general partner of the following entities: Bios Fund I, Bios Fund I QP and BP Directors, LP ("Bios Directors"). Bios Equity Partners II, LP ("Bios Equity II") is the general partner of the following entities: Bios Fund II, Bios Fund II QP and Bios Fund II NT. Cavu Management, LP ("Cavu Management"), an entity managed and controlled by Mr. Kreis, and Bios Capital Management, LP ("Bios Management"), an entity managed and controlled by Aaron Glenn Louis Fletcher, are each a general partner of Bios Equity I and Bios Equity II. Cavu Advisors LLC ("Cavu Advisors"), an entity that is managed and controlled by Mr. Kreis, is the general partner of Cavu Management. Bios Advisors GP, LLC ("Bios Advisors"), an entity that is managed and controlled by Mr. Fletcher, is the general partner of Bios Management.
(2) Mr. Kreis, Cavu Management, Cavu Advisors, Mr. Fletcher, Bios Management and Bios Advisors each share voting and investment control with respect to the shares held by Bios Fund I, Bios Fund I QP, Bios Directors, Bios Fund II, Bios Fund II QP and Bios Fund II NT (collectively, the "Bios Equity Entities"). Because of the relationship between Mr. Kreis, Mr. Fletcher, Cavu Management, Bios Management, Cavu Advisors, Bios Advisors and the Bios Equity Entities, Mr. Kreis, Mr. Fletcher, Cavu Management, Bios Management, Cavu Advisors and Bios Advisors each may be deemed to beneficially own the shares held directly by the Bios Equity Entities.
(3) In consideration of Mr. Kreis' service as a director of the Issuer, Bios Directors was granted options to purchase 3,200 shares of the Issuer's common stock at the exercise price of $10.32 per share. The options granted will vest in equal monthly increments over a 36 month period commencing on December 4, 2021. Under the Issuer's Amended and Restated 2018 Equity Incentive Plan, the options may not be exercised after the tenth anniversary of the grant date.
(4) For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.
 
Remarks:
[none]

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