Exhibit 10.1

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (i) NOT MATERIAL AND (ii) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

This Proposal when executed by Patheon and the Client will become a contract binding on the parties (the “Contract”). The Term of the Contract will be from the Effective Date until completion by Patheon unless specified otherwise. This Proposal is a time-limited offer, which will remain open for acceptance by the Client for 14 days from the issue date above. Following the expiry of this offer, Patheon may, at its sole option, waive the time limit or rescind this offer without further notice to the Client.

Date of Confidentiality Agreement: March 11, 2019

Table of Contents

Part A: Project Overview

Lantern is currently evaluating it’s API LP-300 in a Phase 2 clinical trial. They have requested that Patheon provide a proposal to transfer the previously validated manufacturing process and analytical methods and produce [***] of final API under cGMP.

Technical Expertise

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Reduced Timelines

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Price

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Proposal Introduction

Patheon is an industry leading API Contract Development and Manufacturing Organisation (CDMO) with extensive experience of successfully undertaking programs of work for many established and emerging pharmaceutical companies. The R&D and manufacturing facilities at Patheon’s global network of sites are well- positioned to deliver on Lantern’s requirements for LP-300. The services covered by this proposal will be undertaken at the Florence facility in South Carolina.

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This FDA approved facility [***] is primarily engaged in API process development and manufacture for early clinical phases. [***]

Part B: Project Activities

1. Technology Transfer and Process Evaluation

Goal

To reproduce the Client’s documented procedures on laboratory scale

Complete a non-GMP demonstration batch in a glass reactor.

To carry out process improvement activities to enable safe and robust manufacture on the desired scale

Deliverables

Estimated Duration

Scope

Patheon will begin the project by undertaking laboratory activities to implement and evaluate the process provided by Lantern. This work will be carried out in the chemical and analytical R&D laboratories.

As the transfer and evaluation of each stage of the process is completed, Patheon will carry out a non-GMP demonstration batch in a glass reactor.

Wherever possible, the conditions already established by Lantern will be implemented for scale-up. Sometimes the process supplied by a Client needs to be improved or formally developed in order to be safe and robust for the requested scale-up.

Assumptions

2. Analytical Methods Implementation and Associated Services

Goals

Deliverables

Estimated Duration

Scope

Patheon will carry out analytical method transfer in our R&D laboratories. Once the methods have been qualified in-house, they will be transferred to the Quality Control laboratory/personnel. Impurity/intermediate markers will be either produced in-house or procured if commercially available. [***]. The remaining markers will be produced in-house except for [***].[***] Procurement of this material will be captured as a pass-through cost once a source is identified. All markers will be tested and a Certificate of Testing will be issued.

Assumptions

Already fixed specifications for key raw materials, intermediates, and final product will be provided by the Client prior to commencement of work. If fixed specifications are not available, timelines may be impacted and additional costs may be incurred and will be captured via the Change of Scope process.

All Client-stated available analytical methods, reference standards / marker substances will be provided by the Client to Patheon in good time prior to the start of laboratory process familiarisation. If methods and standards are not provided or prove to be inadequate for the required purpose, timelines may be impacted and additional costs may be incurred and will be captured via the Change of Scope process.

Patheon standard specifications and release testing will be applied to all non-contributory or standard raw materials. If Client-defined specifications are required, timelines may be impacted and additional costs may be incurred and will be captured via the Change of Scope process.

Methods to be Transferred or Evaluated:

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Other Analytical Services

Other analytical services may include the following. Modify/delete as appropriate, including addition of appropriate scope text.

3. Manufacture of GMP Material

Goal

To manufacture approximately [***] of LP-300 under cGMP conditions

Deliverables

Target Quantity: Approximately [***] of LP-300 to the agreed upon specifications on a campaign basis. Lantern will receive all material generated from the campaign (except retains, QC samples, etc)

Campaign Report. Format as per Patheon standard. A report will be issued four to six weeks after release, containing detailed process descriptions, commented scale-up results, and information on key raw materials used for the scale-up. Key analytical data for intermediates and final product will be included.

GMP Documentation: Copies of all GMP Executed Batch Operating Procedures will be provided (incl. deviation/OOS reports, CoA and releases of all raw materials, printouts of all IPC and release tests, cleaning records and temperature charts, and QA sign-off). Master Batch Operating Procedures (BOP) (equivalent to Master Batch Records (MBR)) and Executed Batch Operating Procedures (equivalent to Executed Batch Records (EBR)) in local language (English).

QA-approved TSE/BSE certificate, certificate of compliance/conformity, release for intended application, and batch tree for the GMP batch.

Estimated Duration

Scope

Patheon will transfer the manufacturing process established during the Technology Transfer and Process Evaluation phase of work to the production facility and carry out a production campaign. The target quantity of this campaign will be [***]. This campaign shall be performed under cGMP conditions using water for injection.

Assumptions

The final product will be tested against the following specifications (tentative; to be discussed in good faith):

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4. Stability Studies

Goal

To provide re-test data for LP-300.

Deliverables

Data summaries will be provided to the Client at intermediate time points, and a stability summary report will be provided to the Client following completion of the study.

Estimated Duration:

See table below

Scope

Patheon shall design a stability program to monitor:

The following storage conditions and time points are suggested for testing:

R = release test data

C = contingency (storage; testing only in case of "significant change")

X = characteristics, assay & purity (HPLC), water, XRPD

M = characteristics, assay & purity (HPLC), water, XRPD, microbiology

Assumptions

The Client provided analytical method is stability indicating, confirmed via a forced degradation study. If no forced degradation study has been undertaken, Patheon can arrange at additional cost under a change of scope

5. Raw Materials

6. Additional Services

The following items are formally considered out of the scope of this proposal, but could be offered as additional services:

7. Project Management

Patheon will provide dedicated project management support to monitor the progress of the project against the agreed scope of work and timelines and will provide Lantern with routine updates while there are ongoing billable activities in progress (excluding stability).

Upon award of this project, Patheon will form its project team. A Project Manager / Leader will be assigned to lead the team and be the primary client point of contact from raw material procurement through process implementation, development and production, to shipment of the product. The Project Manager / Leader typically has university degree (Ph.D. or BSc) qualifications in chemistry and significant prior experience with chemical process research and development and API manufacturing

The Project Manager / Leader will typically organise:

The team will also be made up of Lantern personnel as agreed. A formal project kick-off (KO) meeting will be arranged prior to start of work to review the provided technical information and re-confirm that the scope of the project remains as per this proposal.

Part C: Budget Summary

Price Quotation

Costs which cannot be quantified upfront e.g. analytical columns/reagents, external analytical testing, API packaging, shipping charges, custom fees, etc. that must be purchased to run the project will be passed through at [***].

Payment and Delivery Terms

Payment terms: [***]

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Where applicable, please issue purchase orders, referencing Proposal Number [***], to the legal entity which will perform the services covered by this proposal:

Patheon API Services, Inc.

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Please send the purchase order to the following addresses:

E-mail: [***]@thermofisher.com

E-Mail: [***]@patheon.com

E-Mail: [***]@patheon.com

Shipping Options

Part D: High Level Timeline

The timeline below and any estimated activity durations stated above are presented at this stage as a non- binding projected estimate of the milestone durations and deliverables envisioned at the time of issuing this proposal. Patheon will use commercially reasonable efforts to adhere to timeline estimates shown below by initiating the project as soon as a Lantern award by signature is received. All project timelines are however subject to resource and production asset availability at the time the project is awarded. Once awarded, timelines will be reviewed and updated and an updated project plan provided.

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Part E: Standard Assumptions

Financial

All prices presented in the Price Quotation are NET of VAT.

All prices quoted are based on Patheon API Services Inc Tariff 2020.

Any analytical columns/reagents, external analytical testing, API packaging, shipping, and filter media that must be purchased will be charged additionally as pass through costs.

Validity

This offer is valid until July 25, 2020.

Regulatory Management

To support the proposed project and eventual product filing, it is anticipated that Lantern will conduct an audit of Patheon’s site for Quality Assurance purposes. It is assumed that the audit will require one Patheon QA team member for up to two days. If additional resources and/or time are required, these will be considered changes of scope and priced as per the table below.

The regulatory support requirements of Clients vary from project to project. Patheon can provide support for activities such as:

As the extent of regulatory support can be uncertain, hourly rates are normally defined for any required services as per the table below.

Out of Scope

The following activities are not within the normal scope of project activities and may incur additional costs if required:

OEL

Unless otherwise stated above, Patheon assume that the OEL of the raw materials, intermediates and / or product have an OEL of >10 µg/m3. If the OEL is confirmed as lower than >10 µg/m3 after project commencement, a further assessment of the handling requirements will be made which may impact timelines and cost.

Fees include a single revision of documentation. Patheon will invoice the Client on issue of draft report.

For Analytical Out Of Specification (OOS) investigations, Patheon will conduct investigations according to Patheon’s Standard Operating Procedure and report findings to the Client, the costs for which will be borne by the Client should the OOS be a result of the nature of the product rather than Patheon error in processing or testing.

At the Client request, issued documents may need to be updated throughout the life of the project. The requirement for update could be based on, but is not limited to, new stability data or new storage conditions. Documents requiring update may include Certificate of Analysis, specifications, test methods, reports or any other document already issued by Patheon. Any additional costs for the update will be communicated to the Client via the Change of Scope process prior to initiating the documentation change.

If the Client requests Patheon to provide a quarantine release (provisional batch release pending full release for shipment), the Client shall pay Patheon a fee of [***] per-quarantine released batch (fee not included within the Price Quotation) to cover the additional administrative and QA requirements necessary to meet such a request. Patheon makes no warranty of any kind, either expressed or implied of fitness for a particular purpose or warranty of merchantability in respect to the quarantine release.

Deliveries

According to tax law, VAT or customs may have to be charged on the product price in case of delivery destination changes (from 3rd party country to Europe or the other way). This is valid for inbound materials as well as outbound materials. The potential changes have to be evaluated case by case between the Client and Patheon. Delivery destinations have to be communicated well in advance.

Storage

In the event that the Client does not take delivery of a product at the agreed time, Patheon have the option but not the obligation to store the product at its site or through carefully selected external partners. In such a case, the product is deemed delivered by transferring it into the storage facility. Any storage will be subject to a fee and certain terms and conditions which will be discussed and agreed at the time any storage need becomes known.

In addition, the Client and Patheon have to evaluate the customs situation if products are not delivered to the Client within six months after the invoice date. For quantities produced in commercial buildings customs needs to be evaluated immediately upon invoicing.

Product Release by Client

In the event it will be agreed that a product shall be released by the Client, the Client is obliged to carry out such release within the agreed time. Otherwise, Patheon are entitled to release and ship the product.

Provided Goods

Provided goods have to fulfil specifications and other agreed quality criteria and they have to be fit for use.

Cancellation Terms

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Intellectual Property

The term “Intellectual Property” includes, without limitation, rights in patents, patent applications, formulae, trade- marks, trade-mark applications, trade-names, trade secrets, inventions, copyright, industrial designs, data and know-how.

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Part F: Legal Terms and Conditions

Unless otherwise specified in this proposal, the Patheon API Services Inc. General Terms and Conditions of Sale (provided separately with this proposal) apply to the transaction covered by this proposal.

In case of any discrepancies between this proposal and the General Terms and Conditions of Sale the conditions of this proposal shall prevail.

This proposal has been made to the best of Patheon’s knowledge. It is based upon the information available at the time of offering and the assumptions specified in this proposal. Patheon are entitled to adequately amend this proposal, if determining factors have been subject to change.

This proposal is subject to Patheon Management approval.

Project Team Profiles

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Published 6/18 PATH0712